The blast occurred near the Tolip Hotel on Saturday afternoon in Rushdi, a neighbourhood in Egypt’s second city, close to the motorcade of Major General Mostafa al-Nemr, the head of security in Alexandria, an Egyptian security source told Al Jazeera.
The suspected car bomb, which also wounded at least four people, targeted the motorcade, the source said.
State news agency MENA quoted al-Nemr as saying that two people, a policeman and a driver, were killed in the blast.
The Egyptian ministry of interior said that the attack was an assassination attempt against al-Nemr.
Former deputy interior minister Rafiq Habib told Al Jazeera he suspects the perpetrators belong to an “extremist group”, although nothing has been yet confirmed.
“The timing of this explosion, which comes just ahead of the presidential elections, is telling of its objective to sow fear among voters,” Habib said.
“I do not believe that it [the attack] will have any impact on the elections, however. I’m sure there will be huge numbers going to vote,” he added.
Alexandria resident posted photos of smoke rising from the explosion site.